[DllImport("user32.dll")]
    private static extern int GetWindowRect(IntPtr hwnd, out Rect lpRect);

    private Rect GetWindowRect()
    {
      Process[] processes = Process.GetProcesses();
      Process process = null;
      for (int i = 0; i < processes.Length - 1; i++)
      {
        process = processes[i];
        if (process.MainWindowTitle == "MineSweeper")
        {
          break;
        }        
      }     

      Rect rect = new Rect();
      GetWindowRect(process.MainWindowHandle, out rect);

      return rect;
    }

Rect rect = GetWindowRect();

      int left = rect.Left;
      int top = rect.Top; 

      int centerleft = 21;  //偏移
      int centertop = 93;
      int centerwidth = 300;
      int centerheight = 300;
      
      Bitmap bitmapCenter = new Bitmap(centerwidth, centerheight);
      using (Graphics graphics = Graphics.FromImage(bitmapCenter))
      {
        graphics.CopyFromScreen(left + centerleft, top + centertop, 0, 0, new Size(centerwidth, centerheight));
        this.pictureBox1.Image?.Dispose();
        this.pictureBox1.Image = bitmapCenter;
      }

[DllImport("user32")]
    private static extern int mouse_event(int dwFlags, int dx, int dy, int cButtons, int dwExtraInfo);

    const int MOUSEEVENTF_MOVE = 0x0001; //移動(dòng)鼠標(biāo)
    const int MOUSEEVENTF_LEFTDOWN = 0x0002; //模擬鼠標(biāo)左鍵按下
    const int MOUSEEVENTF_LEFTUP = 0x0004; //模擬鼠標(biāo)左鍵抬起
    const int MOUSEEVENTF_RIGHTDOWN = 0x0008; //模擬鼠標(biāo)右鍵按下
    const int MOUSEEVENTF_RIGHTUP = 0x0010; //模擬鼠標(biāo)右鍵抬起
    const int MOUSEEVENTF_MIDDLEDOWN = 0x0020; //模擬鼠標(biāo)中鍵按下
    const int MOUSEEVENTF_MIDDLEUP = 0x0040; //模擬鼠標(biāo)中鍵抬起
    const int MOUSEEVENTF_ABSOLUTE = 0x8000; //標(biāo)示是否采用絕對(duì)坐標(biāo)

        int clickPointX = X * 65535 / Screen.PrimaryScreen.Bounds.Width;
        int clickPointY = Y * 65535 / Screen.PrimaryScreen.Bounds.Height;

        //移動(dòng)鼠標(biāo)
        mouse_event(MOUSEEVENTF_ABSOLUTE | MOUSEEVENTF_MOVE, clickPointX, clickPointY, 0, 0);

        //左鍵點(diǎn)擊
        mouse_event(MOUSEEVENTF_LEFTDOWN | MOUSEEVENTF_LEFTUP, 0, 0, 0, 0);
        
        //右鍵點(diǎn)擊
        mouse_event(MOUSEEVENTF_RIGHTDOWN | MOUSEEVENTF_RIGHTUP, 0, 0, 0, 0);