from __future__ import print_function
import resource
class A(object):
 def __init__(self):
 self.a = 'string'
 self.b = 10
 self.c = True
class B(object):
 __slots__ = ['a', 'b', 'c']
 def __init__(self):
 self.a = 'string'
 self.b = 10
 self.c = True
def test(cls):
 mem_init = resource.getrusage(resource.RUSAGE_SELF).ru_maxrss
 l = []
 for i in range(500000):
 l.append(cls())
 mem_final = resource.getrusage(resource.RUSAGE_SELF).ru_maxrss
 del l
 print('Class: {}:\n'.format(getattr(cls, '__name__')))
 print('Initial RAM usage: {:14,}'.format(mem_init))
 print(' Final RAM usage: {:14,}'.format(mem_final))
 print('-' * 20)
if __name__ == '__main__':
 import sys
 test(globals()[sys.argv[1].upper()])

❯ python mem_test.py a
Class: A:
Initial RAM usage: 4,890,624
 Final RAM usage: 200,454,144
--------------------
❯ python mem_test.py b
Class: B:
Initial RAM usage: 4,919,296
 Final RAM usage: 60,235,776

In [2]: %pycat ref_example.py
from weakref import ref
class A(object):
 __slots__ = ['b']
 def __init__(self):
 self.b = 1
class B(object):
 __slots__ = ['b', '__weakref__']
 def __init__(self):
 self.b = 1
In [3]: from ref_example import *
In [4]: a = A()
In [5]: r = ref(a)
---------------------------------------------------------------------------
TypeError     Traceback (most recent call last)
<ipython-input-6-75a6d689c8b3> in <module>()
----> 1 r = ref(a)
TypeError: cannot create weak reference to 'A' object
In [6]: b = B()
In [7]: r = ref(b)
In [8]: r
Out[8]: <weakref at 0x109199578; to 'B' at 0x10919f890>